I have a pretty solid nicotine tolerance and like a big bowl of something strong in the morning when satisfying my caffeine and nicotine addictions... But like others have said, it really depends... I can't always get away with big bowls of high octane stuff outside of that first pipe of the morning. I just got my ass kicked by a bowl of HH Rustica in an Ashton with a 1.66" x .76" chamber. Too much for me tonight. Had to abort with probably 15% or so remaining. I usually smoke these types of blends in medium sized or smaller chambers after the morning.As the boys said for some of us it is, and for some of us it ain't. For a few tobaccos I must be sure to have just eaten. HH Rustica on an empty stomach is really bad for me.
I would definitely recommend using smaller chambers for more powerful blends instead of skipping them entirely. Don't be afraid to try the heavy hitters, just smoke smaller bowls or for shorter sessions until you know you can handle more. Many of the strongest blends tend to taste better in medium or or smaller sized pipes in my experience as well.
On the flipside, I really love a nice, long smoke of a Latakia blend some evenings. For me, these blends tend to be full of flavor but low in nicotine. Perfect for packing a huge bowl and enjoying everything they have to offer.