We have good friends who did this for three years -- had planned on 2 but added a year.
They said their only mistake was starting out in a much larger RV than they needed. (Money was NOT an issue for them.) Six months in they downsized, realizing they didn't need quite as much room, trading/buying a somewhat smaller, but very nicely appointed rig that still had the power to tow their little Suzuki. (This thing still had a queen-bed stateroom, comfy salon that bumped out, nicer electronics than my house, etc. But they found it easier to navigate through mountains, cities etc.
They loved it and, with internet, were able to keep their business on a slow boil and stay well in touch with folks.