Living here in the armpit of Florida (North Central, Micanopy to be exact), it's humid most of the year. But when it's not humid, man it can be really, REALLY dry, and my body being so used to the humidity, sometimes has a hard time transitioning. It's at these times when I absolutely cannot smoke Latakia blends. There is something drying in the nature of tobacco to begin with, but something about the Latakia, and possibly the astringency of the orientals, is not conducive to the dry weather. That could be my own biology, but I think it's an overall elemental thing.
I've also noticed that if I put too much flame to the tobacco, the next several puffs taste more burnt, acrid, and unpleasant, possibly because the sugars and other elements in the tobacco just got too hot, and once those parts that were subjected to too much flame have burnt to ash, the good flavor comes back. I only notice this when I pay close attention, I don't sit there and baby the pipe all sensitive-like all the time. I enjoy picking up in this sort of thing, but I can definitely tune it out and just puff away.
I love the minutae. Kill me. But I certainly don't get lost in it. If I think of more, I'll chime in. But there are folks here that know far more than I do. If you ever wanna talk about minutae of pipe lighters and hemp wicks let me know...