I think it can happen with anything, really. I usually smoke C&D poplar camp daily. However I do switch my tobacco up every 4 or 5 days no matter what. Sometimes English, or a solid burley. Recently it was Dutch masters whiskey. I figure, this way I’ll never get flavor fatigue from a blend. It’s part of the reason I buy new blends in smaller amounts every order.
Possibly, but I think smokers figure themselves out eventually. I've been loving straight VA's for a long time, and I can't imagine getting 'straight VA fatigue'. I mostly don't care for red VA's, but never liked them. And a few blenders do them well, so that's not really 'fatigue'.