A few questions and assumptions first... I assume that you mean mixing it with a Virginia. Shredded Virginia? Is the Virginia already moist, or dry like a tobacco processor would get? Are you pressing it, or rolling it into twists? Is the Virginia (or blending leaf) palatable already?
If you are talking about working with whole leaf, then you'd just be mixing dry components together, which isn't going to meld the flavors very much, very fast. You can mix these, but you'd probably want to let the flavors meld for a much greater length of time.
Also, your aspirations... If you prefer C&D style Vapers, you might go for a dryer blend. However, if you prefer a more refined melded flavor, you might spritz it with distilled water or steam. I prefer steam. But, then you have to contend with mold issues, especially if jarred for aging. I have found that whole leaf will mold pretty quickly if just water is used. Honey, food quality mold inhibitors, and citric acid seems to work best for me. Of course the latter two are in their experimental phases for me.
Pressing or twisting, you will have to do something to rehydrate the leaf. Plugs just don't stick, and twists won't even roll correctly till rehydrated. Plugs need the natural stickiness of the rehydrated natural sugars to meld to stay in plug form. Otherwize, you just end up with a stack of well ironed leaf that falls apart.
If you are talking about a tinned blending perique mixed with a tinned Virginia, then you can get away with just mixing these and processing them as you like.
I will add this thread to my favs, to see what others suggest also. Maybe I can add a new trick to my bag as well. :
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