I've only been affected by nicotine one time and it wasn't relaxing at all. I smoked two back to back bowls of C&D Big & Burley and got super sick and this was right after supper (no it wasn't because of what I ate or the portions, which were light). I'm usually not sensitive to nicotine, but that night it sure floored me. Talk about hugging the toilet, I think my handprints are still around the bowl. Since that time, no back to back bowls of a high nic blend for me.