Heck ya, I've smoked just about everything that's smokable in my car/truck.
So here's the deal. Most people don't know the proper way to use a microwave oven, and most smokers don't know the proper way to smoke in a vehicle.
Rule #1
Make sure the AC/HEAT/VENT is set to "FRESH" air! That's the button that shows an arrow of the air flow from outside to inside. If your running AC do
not switch to "MAX AC" That defaults to "Recycled" air. And make sure the fan is set to at least medium speed.
Rule #2
Only ONE window can be cracked in the vehicle. If your smoking in the drivers seat, it should be the drivers window. And it should only be cracked about 1-2 inches.
So think of a vehicle as an enclosed vessel. If you close ALL the windows and set your vent to FRESH air, it's creating pressure within the vessel (vehicle). Now crack a window, and that pressure (along with your smoke) will cause the air flow (along with your smoke) to exit the pressure vessel through the only crack available, and it will exit at a volume directly associated with the fan speed. If you have your system on recycle air (or MAX AC), there is no pressure at all, and it's simply recycling the smoky air in the vehicle and bringing in outside air through that cracked window. You can watch the smoke go right out the window. Switch the system to recycle and watch what the smoke does.
Do this and you can smoke whatever you like, it won't pollute your air ducts, and people sitting in the vehicle will not notice the smell or smoke, as long as rule #2 is followed. If your passenger cracks a window, all bets are off... now the air goes out both cracks.
I'm a big proponent of smoking while driving!