The two blends that have bitten me the worst are 3 Castles, a Virginia, and Virginia No. 1. I used to smoke 3 Castles in RYO cigarettes and thought they were delicious. I smoked it once in a pipe and to my great surprise it bit like crazy, when it didn't bite at all smoked in a cig. This was more than a decade ago and I haven't smoke any since, though I still have some dried up somewhere.
I smoked Virginia No. 1 for the first time around 2010. It bit like a viper so I threw my baggie in one of my bins and forgot about it. When I rediscovered it last year, it was still moist(!) and I smoked some. This time, there was the merest of tingles and no bite. It didn't taste bad at all. I don't know if I've developed a tolerance or the tobacco had changed over time.
I should note that I had been smoking the pipe for quite a few years when I first tried the two aforementioned blends.
So, I'd suggest if a blend bites now, put it aside and come back to it later. The bite may go away for whatever reason.
