Yes, the different colors are in fact different types of pipe cleaners and by different makers. Some are fluffy, some tapered, others bristled, etc. over time we all develop a preference for which types we like. The boxes I post above are for when I sit down to do a batch cleaning, usually on Sundays. For my daily pipe cleaners I am not so organized. Typically I just use the red or blue cleaners because they have more firmness compared to BJ Longs standard cleaners.