'tango, if you only get reflux with Latakia, and are happy without it, you are lucky. Reflux can mess up your esophagus (food tube), so avoid any regular problem with that. One low dose OTC med helps me avoid reflux, with an extra now and then if I eat supper late or eat a heavy meal. My only direct identifiable problem with pipe blends has been mouth burn with some aromatics. I think Latakia is overused in pipe blends, but I do enjoy a number of Lat blends. Not really necessary to use it in every second blend in my 'umble opinion.