I've not driven all the way from Eureka to Brookings on the 101. I live in the Illinois Valley/Siskiyou Mountains and have driven from there to Brookings an innumerable amount of times. It's about a 1hr 15 min drive for me.So, have you driven that desolate stretch of highway? Pretty in many ways, but grim in others.
The Redwood Highway drive that I'm referring to is likely less grim than the one you're referencing above because it's more ecologically and biologically diverse, you drive through the redwoods, and many of the homes are opulent vacation homes right along the Smith River.
I think you're more likely to see dilapidated homes and rural, geographically isolated poverty on the stretch of the 101 you're referring to because more people actually live there year-round, most of whom are blue collar, just like where I live. You're an hour from a grocery store most places on the California/Smith River side of Redwood Highway so there are many more 'vacation getaways' in the Smith River area.