The people who track such things know EXACTLY the location of the data-center-sized "spam companies" around the world. As in, what buildings, and what rooms and floors OF the buildings.
And we now have cruise missiles that are targetable within two meters. They fly under radar---literally. And they can be launched from international waters, so getting within range is no biggie.
Once to show you've had enough, then a second strike to make clear you can do it all day, every day... and an extended period of World Spamless-ness would begin. Everyone, everywhere, would be smiling (except the A-holes, of course.)