Tobacco Exchange on Exchange Place in the French Quarter has a smoking lounge and a nice choice of jar and tinned tobaccos. They have a huge supply of pipes as well. There is a cigar shop off Bourbon, on St. Peter's street, I believe, that has some pipe tobacco as well, such as Dunhill bulk blends and Goedewaagen, which I think is MCClelland Tastemaster. The Epitome pipe shop is in the mall on the beach in Gulfport Mississippi. Payless Pipes is on St. Charles Avenue, opposite of the French Quarter, but I have never been there.
BTW, most of the bars in the Quarter allow smoking.